Oral Biol Res 2018; 42(4): 198-207  https://doi.org/10.21851/obr.42.04.201812.198
A study of bone regeneration effect according to the two different graft bone materials in the cranial defects of rabbits
Hyun-Jong Song1, Hyun-Woo Kim2, Gwi-Hyeon Min2, Won-Pyo Lee2, Sang-Joun Yu2, Byung-Ock Kim2*
1Department of Dentistry, Suncheon Hankook Hospital, Suncheon, Korea
2Department of Periodontology, School of Dentistry, Chosun University, Gwangju, Korea
Correspondence to: Byung-Ock Kim, Department of Periodontology, School of Dentistry, Chosun University, 303 Pilmun-daero, Dong-gu, Gwangju 61452, Korea. Tel: +82-62-220-3850, Fax: +82-62-224-4664, E-mail: bobkim@chosun.ac.kr
Received: December 11, 2018; Revised: December 12, 2018; Accepted: December 13, 2018; Published online: December 31, 2018.
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Guided tissue regeneration (GBR) has been used to promote new bone formation in alveolar bone reconstruction at defective bone sites following tooth loss. Bone grafts used in GBR can be categorized into autogenous, xenogenous, and synthetic bones, and human allografts depending on the origin. The purpose of this study was to compare the rates of bone regeneration using two different bone grafts in the cranial defects of rabbits. Ten New Zealand rabbits were used in this study. Four defects were created in each surgical site. Each defect was filled as follows: with nothing, using a 50% xenograft and 50% human freeze-dried bone allograft (FDBA) depending on the volume rate, human FDBA alone, and xenograft alone. After 4 to 8 weeks of healing, histological and histomorphometric analyses were carried out. At 4 weeks, new bone formation occurred as follows: 18.3% in the control group, 6.5% in group I, 8.8% in group II, and 4.2% in group III. At 8 weeks, the new bone formation was 14.9% in the control group, 36.7% in group I, 39.2% in group II, and 16.8% in group III. The results of this study suggest that the higher the proportion of human FDBA in GBR, the greater was the amount of clinically useful new bone generated. The results confirm the need for adequate healing period to ensure successful GBR with bone grafting.
Keywords: Allografts, Bone substitutes, Guided tissue regeneration, Heterografts

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